Corona virus – Corona vaccination reduces the risk of long-term Covid infection

In the midst of the summer corona wave, three research teams confirmed that vaccination against the Sars-CoV-2 virus has an extremely positive effect: vaccines not only prevent infections, severe courses, hospital stays and deaths, but also reduce the risk of suffering long-term consequences.

So far, it has not been clear whether vaccination will reduce the risk of further acute and long-term effects of coronavirus infection. The disease called Long Covid is accompanied by, among others, weeks or months of exhaustion, forgetfulness and a feeling of constant overwhelming, shortness of breath and fatigue. According to US teams, vaccines are effective against this disease, and this effectiveness builds up with the number of doses.

These three publications can be found in the Journal of the American Medical Association (Jama), one of the world’s most respected medical journals. Elena Azzolini from the IRCCS Humanitas Research Hospital in Milan and her Italian co-authors published there a research study on the effects of Covid-19 vaccination on the occurrence of long-term health problems caused by Long Covid after the disease.

Almost a quarter of a million fewer deaths in the US

From March 2020 to April 2022, workers from nine Italian healthcare facilities were monitored with regular PCR tests. 2,560 people participated in the study. Of these, 739, or 29 percent, developed Covid-19 disease, causing Long Covid symptoms in a total of 31 percent of patients. This percentage improved over time: it was 48.1 percent in the first wave of Covid-19, eventually dropping to 16.5 percent in the third wave at the end of the observation period.

Each dose of the vaccine made a difference: 48.1 percent of those unvaccinated with Covid-19 developed Long Covid. 30 percent with the disease suffered from this disease after just one dose of the vaccine, 17.4 percent. after two doses of the vaccine, and finally 16 percent. after three doses of the vaccine and the disease continued to develop.

The special group was devoted to the American pharmaceutical information service IQVIA, Johns Hopkins University in the US state of Maryland and the National Basketball Society in the USA. 2613 basketball players and members of their teams signed up for the team. Subjects had to be vaccinated at least twice by October 1, 2021, and the third partial vaccination against Covid-19 by January 5, 2022. Participants were on average 33.7 years old and healthy, but spent a lot of time having basketball as a team sport during joint trainings and games in the hall. At the end of the study period, 85 percent had received a third suture.

Effect according to the authors: the third partial vaccination reduced the risk of asymptomatic infections by 57%. Symptomatic infections were up to 61 percent. less frequent. “This study showed that in young, healthy, well-vaccinated groups of people with frequent Sars-CoV-2 checks, the booster dose resulted in significantly fewer infections,” concluded study leader Caroline Tai of IQVIA.

A study by a team led by Molly to estimate the number of Covid-19 infections, hospital admissions for disease, and severe deaths, based on massive US-wide datasets from December 1, 2020 to September 30, 2021 Steele of Atlanta State Disease Control Centers.

16 million cases of Covid-19 and 310,000 deaths were registered in the US prior to vaccination against Sars-CoV-2 between January 19 and December 12, 2020. Model calculations taking into account the vaccination campaign that began in the US on December 12, 2020 show significant results by the end of September 2021: “Covid-19 vaccination has an estimated 27 million Sars-CoV-2 infections, 1.6 million hospital admissions and 235,000 deaths were avoided,” says Steele.

The relative effectiveness of Covid-19 was finally calculated for September 2021. Accordingly, there were 52% fewer infections, 56% fewer hospital admissions, and 58% fewer deaths than without vaccines.

A German vaccination study shows why breakthrough infections still happen. So how well a vaccine protects depends on the strength of the antibody response someone makes against the virus, and it depends on the person. Germany’s largest vaccination study, carried out by the medical department of the University of Duisburg-Essen, has been running for over a year.

Why breakthrough infections still exist

The research team regularly took blood samples after the first, second and third immunizations and determined the amount of antibodies against the Sars-CoV-2 virus – known as antibody titers. In addition, participants answered questions about their health status and whether they had developed a corona infection despite vaccinations.

The research team published its first study results in the renowned journal Frontiers in Immunology, which included data from 1,391 participants. Between late November 2021 and early March 2022, 102 people, or seven percent, contracted the omicron variant of the coronavirus despite a booster dose. Most of the infections took place in the private sphere.

“The good thing is that everyone who was infected was sick for a short time and was mild, akin to a cold,” says Winfried Siffert, head of the Essen Institute of Pharmacogenetics. Therefore, it is worth making the fourth seam.(estimate)

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