Good news from Lauterbach: BA.2.75 doesn’t work

Germany is currently experiencing a violent summer wave with over 1.8 million people now infected. According to the Robert Koch Institute, more than 96,000 infections occur on average 7 days a day. Responsible for this is the sub-variant BA.5 omicron, which has meanwhile largely replaced all other variants. According to the current weekly report of the Robert Koch Institute, it is already responsible for 83 percent. infection. The number of unreported cases is likely to be much higher.

BA.2.75 cases have already been registered worldwide – including Germany

In the midst of this violent summer wave, news recently surfaced that a threatening new variant is spreading worldwide: BA.2.75. According to the World Health Organization (WHO), this is a subset of the BA.2 variant that was first identified in May

they appeared in India and are spreading rapidly there. There have also been cases in Canada, New Zealand, Australia, Great Britain and Germany.

Even the Robert Koch Institute found out about this variant. The current weekly report says: “The growth and rapid spread of BA.2 BA.2.75 is currently being observed in various regions around the world, including India. So far, three genome sequences have been found in a sample in Germany which show the characteristic BA.2.75 mutations. ” While there is no international data on virulence and immune flight, the observed spread and mutation profile indicate that this variant can very quickly and as a result the number of people infected and hence the burden of the disease also increases more, in line with the RKI.

Lauterbach: BA.2.75 cannot be approved in many countries

Ironically, Karl Lauterbach, who is not entirely known for his optimism, is now making everything clear. “Good news, though for now. So far, the data does not look like the BA.2.75 variant. can win, “he wrote on Twitter.

India’s BA.2.75 distribution is falling again

It refers to an image published by Mike Honey, Australian Data Officer. It comes from gisaid.org, the public virus sequence database, and shows the countries with the highest prevalence of BA.2.75 from May 29 to July 10.

Accordingly, Nepal experienced a sharp rise in June with the line detected in more than 20 percent of the sequence. Also in Australia, an increase to almost five percent by July 10 was detected.

An interesting fact is that in India, where BA.2.75 was first recorded, the spread has been declining since the end of June. Even in countries such as Canada, Indonesia, Japan, New Zealand, and the US where the line was detected, there was no major increase over the period specified.

So this is good news for Germany because obviously BA.2.75 cannot claim like BA.5 for example. As Lauterbach points out, the good news is only “preliminary”.

BA.2.75 has many changes in the spike protein

Scientists have so far agreed that the new variant has everything it takes to end the BA.5 triumph. in

“Guardians”

who calls the new subline “Centaurus,” virologist Tom Peacock stated, “It is definitely a potential candidate for what’s to come after BA.5.”

The most worrying are the changes in the spike protein. “BA.2.75 has eight mutations in addition to the 29 mutations that BA.2 already has in the spike protein. It can be assumed that such an abundance of new mutations will further enhance the properties that weaken immune protection, “said Ulrich Elling of the Institute of Biotechnology to”

FROM DF

“.

A BA.5 infection may provide little protection against infection

Paw wrote

on Twitter

that changes in mutations don’t force you to sit down and pay attention when viewed individually, but that they all appear together is another matter. Because the virus may be able to bypass the immune system through mutations even better than the BA.2 omicron subline, which dominated here until around June, it has already done so. This means it can spread even faster and infect even more people because vaccination or recovery does not protect against infection.

American virologist Jesse Bloom pointed to another danger
Twitter
hin: First of all, the BA.5 variant, which is currently dominant in our country, may offer little protection against infection. He warned that only those who have already had BA.1 infection are likely to be better protected against reinfection.

So if BA.2.75 doesn’t become dominant here, it could be an advantage for us. Time will tell if Lauterbach’s provisional “good news” will come true.

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