Doctors before a breakthrough in treatment

gluten intolerance significantly reduces the quality of life of those affected. this chronic autoimmune diseaseit’s on one gluten intolerance regressing is not yet curable. So far, the only solution: avoid eating gluten-containing foods for the rest of your life.

Hope for people with celiac disease now creates them Studies from Mainz. Scientists have one there new medicinal substance developed to treat gluten intolerance – it is the first of its kind.

The first celiac drug with proven effectiveness

Name of the new active substance: ZED1227. In a Phase 2a clinical trial, Mainz researchers and international colleagues demonstrated that ZED1227 has a strong protective effect on the mucosa of the small intestine and reduces inflammation, disease symptoms and Improving the quality of life of those affected. So this is ZED1227 the first drug for celiac diseasefor which clinical efficacy can be proven. The research results were published in the world-famous New England Journal of Medicine.

“People with celiac disease experience considerable suffering from the constant need to take care of their diet. Thanks to the ZED1227 transglutaminase inhibitor, a pharmacological treatment option will be available in the future to support a gluten-free diet, which will also ensure a significant increase in safety and quality of life ”- explains Prof. Dr. Detlef Schuppan, who is the first author of the study together with prof. Markku Mäki (Tampere, Finland).

Celiac disease is one of the most common inflammatory diseases of the small intestine. Almost one percent of the world’s population is affected. Autoimmune disease is caused by the consumption of gluten, a protein found in various grains such as wheat, rye, barley, and spelled. The disease can have different symptoms, such as diarrhea and abdominal pain, but also different symptoms outside the gut, including various autoimmune diseases.

Severe damage in untreated celiac disease

If inflammation of the small intestine caused by even the smallest amounts of gluten-containing foods lasts longer, it is called the villi, that is, the bulges of the mucosa of the small intestine, recede. This reduces the surface area of ​​the intestinal mucosa. As a result, those affected may absorb less nutrients from their food. Untreated celiac disease can lead to serious complications such as anemia, bone loss, growth retardation, infertility, and small intestine tumors.

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In a recently published efficacy study, participating patients voluntarily underwent daily gluten exposure and two endoscopies. The active pharmaceutical ingredient of ZED1227 was administered in the form of a tablet in three different doses. The fourth group of patients received a placebo. The drug prevented gluten inflammation and villi shrinkage at each dose. The highest dose turned out to be the most effective. In addition, the symptoms typical of celiac disease and the perceived quality of life improved with each dose of the drug.

However, it will still be some time before those affected can use the medicine: a larger follow-up study is initially planned from fall 2021.

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